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KMID : 1098420180260020157
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Korean Journal of Medicinal Crop Science
2018 Volume.26 No. 2 p.157 ~ p.169
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A 26-Week Repeated Oral Dose Toxicity Test and a 4-Week Recovery Test of Cassia tora L. Water Extract in Sprague-Dawley Rats
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Nho Jong-Hyun
Lee Mu-Jin
Jung Ho-Kyung
Jang Ji-Hun
Sim Mi-Ok
Jang Min-Cheol
Yong Ju-Hyun
Seo Heung-Sik
An Byeong-Kwan
Kim Jong-Choon
Cho Hyun-Woo
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Abstract
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Background: Cassia tora L., an annual or perennial plant of the Fabaceae family, is traditional medicine with various biological activities, including anti-constipation and, anti-inflammation. Chemical compounds such as anthraquinone glycoside and naphthalene derivatives have been isolated from this plant. Cassia tora L. is a common contaminant of agricultural commodities, but is toxic to cattle and poultry.
Methods and Results: To investigate the potential toxicity, Cassia tora L. aqueous extract (CO) was administered orally to rats for 26 weeks at 0 (control), 300, 1,500 and 3,000㎎/㎏/day (n = 10 for male rats for each dose). The positive control comprised animals orally administered anthraquinone 100㎎/㎏/day. There was no treatment-related mortality. An increase in the kidney weight was observed at 3,000㎎/㎏/day of CO and anthraquinone 100㎎/㎏/day. Macrophage infiltration in the colon was observed at CO 1,500 and 3,000㎎/㎏/day and anthraquinone 100㎎/㎏/day, but there were no significant toxicological changes in the incidence and severity of the finding.
Conclusions: The oral no-observed-adverse-effect level (NOAEL) of CO was 3,000㎎/㎏/day in male rats and no target organs were identified. In addition, 300㎎/㎏ was found to be the no-observed-effect level (NOEL) for systemic toxicity under the conditions of the study.
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KEYWORD
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Cassia tora L., Herbal Medicine, Anthraquinone, Chronic Toxicity, NOEL (No Observed Effect Level)
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